颅内Willis环三维稳态及非稳态血液动力学计算(PDF)
《西安交通大学学报》自然版[ISSN:0253-987X/CN:61-1069/T]
- 期数:
- 2008年第04期
- 页码:
- 492-496
- 栏目:
- 出版日期:
- 2008-04-10
文章信息/Info
- Title:
- Dimensional Steady/Unsteady Blood Flow in the Circle of Willis
- 文章编号:
- 0253-987X（2008）04-0492-05
- 作者:
- 陈珍1; 袁奇1; 申娜1; 崔长琮2; Yong ZHAO3
- 1.西安交通大学能源与动力工程学院，710049， 西安; 2.西安交通大学医学院第一附属医院， 710061， 西安；3.School of Mechanical ＆ Aerospace Engineering， Nanyang Technological University， 639798， Singapore
- Author(s):
- CHEN Zhen1; YUAN Qi1; SHEN Na1; CUI Changcong2; Yong ZHAO3
- 1. School of Energy and Power Engineering， Xi′an Jiaotong University， Xi′an 710049， China； 2. The First Affiliated Hospital of Medical College， Xi′an Jiaotong University， Xi′an 710061， China； 3. School of Mechanical ＆ Aerospace Engineering， Nanyang Technological University， Singapore 639798, Singapore
- Keywords:
- circle of Willis; ; blood flow; ; blood dynamics; ; steadystate flow; ; pulsatile flow
- 分类号:
- Q811.2
- DOI:
- 0253-987X（2008）04-0492-05
- 文献标识码:
- A
- 摘要:
- 为了解颅内Willis环中正常与非正常情况下的血液流动状况，帮助临床医生更深入了解Willis环的作用，利用核磁共振成像数据以及计算机辅助设计软件建立了一系列三维Willis环的计算模型，其中包括医学上常见的一些变异、病变症状．给出了在各种物理模型下的血液定常稳定流和非定常脉动流的仿真结果，包括血液流量分配和壁面剪切应力的分布，证实了在Willis环内动脉粥样硬化病变与低的壁面剪切应力有关．该项研究对于临床治疗脑血管疾病具有重要指导作用．
- Abstract:
- The objective of this research was to provide a better insight into the blood flow dynamics in healthy and diseased circle of Willis. A threedimensional computational model is developed combining magnetic resonance data with computeraided design software. The most important anatomical variations were simulated under both steady and unsteady flow conditions， and the distribution of blood flow rates and wall shear stresses were thus revealed. These results suggest that low wall shear stress is a hemodynamic factor in the development of atherosclerotic plaque. A methodology of cerebral hemodynamic modeling is proposed as a potential diagnostic tool for future clinic applications.
参考文献/References
［1］SEMPERE A F. Computational models of blood flow in the circles of Willis ［D］. Leeds， UK： University of Leeds， 2000.
［2］HILLEN B， HOOGSTRATEN H W. A mathematical model of the flow in the circle of Willis ［J］. Journal of Biomechanics， 1986， 19(3)： 187194.
［3］MOORE S， DAVID T， CHASE J G， et al. 3D models of blood flow in the cerebral vasculature ［J］. Journal of Biomechanics， 2006， 39(8)： 14541463.
［4］张致身.人脑血管解剖与临床 ［M］.2版.北京：科学技术文献出版社，2004：397408.
［5］罗小玉.动脉狭窄时的血流动力学研究 ［D］.西安：西安交通大学航天航空学院，1990.
［6］聂永梅，陈槐卿，蒋文涛.动脉粥样硬化模型中颈动脉分叉流场的数值模拟［J］.航天医学与医学工程，2006，19(2)：134138.
NIE Yongmei， CHEN Huaiqing， JIANG Wentao. Numerical simulation of carotid bifurcation flow field in atherosclerosis model ［J］. Space Medicine ＆ Medical Engineering， 2006， 19(2)： 134138.
［7］YUAN Qi， CHANG Ye， FENG Zhenping， et al. CFD simulation of the blood flow in the circle of Willis ［C］∥ Proceeding of the 2nd World Congress for Chinese Biomedical Engineers. Beijing： Chinese Society of Biomedical Engineering， 2004： 212214.
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